I have a very serious life threatening medical condition. I purchased this kit and wasn't sure how to start. I read the entire chapter from the herbal book that talks about doing this. I decided to start very slow. I took just 5 drops of each tincture in the beginning, once a day. I continued that for a long time, probably 2-3 weeks. I wasn't experiencing any changes, positive or negative, but like I said, because of my health I felt that I needed to go slow. I then upped my dose to 10 drops once a day. After doing that for a few days, I went up to 15 and eventually 20, until I finished every drop in every bottle. I only did it once a day and I always took them sublingual rather than swallowing. I never experienced any negative effects. I am happy to report that this does appear to have helped me. TMI, but my bowels are moving every single day. Even on days where I can't eat much. Before, I would go only 2-3x per week. I think the pricing might be off because the way it's priced right now you can buy the four individual tinctures for less than the price of the kit. I will happily purchase again and will likely try to do it 3-4x a year.